{"product_id":"creatine-pure","title":"Creatine Pure","description":"\u003cp\u003e\u003cb\u003eDiscussion\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e• Supports Muscle Performance*\u003c\/p\u003e\n\u003cp\u003e• Supports Brain Function*\u003c\/p\u003e\n\u003cp\u003e• Supports Cellular Energy Production*\u003c\/p\u003e\n\u003cp\u003e• Supports Lean Muscle Mass*\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClinical Applications\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e*These statements have not been evaluated by the Food and Drug Administration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eCreatine PURE\u003c\/i\u003e\u003c\/b\u003e\u003ci\u003e plays a vital role in the energy production process in muscle cells, making it the perfect supplement\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eto fuel muscle health. Whether you are a trained athlete or simply want to help maintain lean muscle mass during\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003ethe natural aging process, creatine supports muscle performance when combined with exercise. Creatine may\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003ealso support cognitive function, helping to keep both brain and brawn at peak performance.*\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCreatine PURE\u003c\/b\u003e features pure creatine monohydrate, an extensively studied supplemental form of creatine.\u003c\/p\u003e\n\u003cp\u003eThis compound has a well-established vital role in cellular energy production, helping to fuel muscle health in\u003c\/p\u003e\n\u003cp\u003epeople of all ages and athletic abilities.\u003cspan\u003e1\u003c\/span\u003e Creatine stores phosphate groups as phosphocreatine, which then\u003c\/p\u003e\n\u003cp\u003edonates the phosphate groups to adenosine diphosphate (ADP) to regenerate it to adenosine triphosphate\u003c\/p\u003e\n\u003cp\u003e(ATP), the primary cellular energy source. Approximately half of the creatine needed by the body is produced\u003c\/p\u003e\n\u003cp\u003eendogenously from the amino acids arginine, glycine, and methionine. Creatine can also be obtained through\u003c\/p\u003e\n\u003cp\u003edietary sources, primarily meat and fish. Individuals who consume a predominantly plant-based diet have been\u003c\/p\u003e\n\u003cp\u003esuggested to have lower creatine accumulation and a greater response to creatine supplementation.\u003cspan\u003e*2,3\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eAlthough 95% of creatine is stored in muscles, it is also found in heart, brain, kidney, retinal, and testicular tissues.\u003c\/p\u003e\n\u003cp\u003eCreatine levels can be impacted by diet, physical activity, and a natural decline that occurs with aging. The body\u003c\/p\u003e\n\u003cp\u003emetabolizes 1% to 2% of stored creatine daily into the waste product creatinine, which is excreted in the urine.\u003cspan\u003e2,4\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eThe primary benefit of creatine supplementation is to replenish cellular energy by raising phosphocreatine to\u003c\/p\u003e\n\u003cp\u003eaccelerate the recycling of ADP to ATP, which is how it helps support muscle performance.\u003cspan\u003e5\u003c\/span\u003e However, other\u003c\/p\u003e\n\u003cp\u003etissues that store creatine may also benefit from enhanced cellular energy production. Individual responses to\u003c\/p\u003e\n\u003cp\u003ecreatine supplementation can vary based on diet, body composition, and intensity of physical activity.*\u003cspan\u003e2,6\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCreatine Supplementation Approaches\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCreatine loading refers to a supplementation strategy used to increase creatine stores in skeletal muscle\u003c\/p\u003e\n\u003cp\u003eand involves supplementing with an oral dosage of 20 to 25 g\/d for 5 to 7 days.\u003cspan\u003e2,5\u003c\/span\u003e Creatine loading doses\u003c\/p\u003e\n\u003cp\u003eare typically divided into 4 to 5 servings per day, a practice found to help mitigate gastrointestinal distress\u003c\/p\u003e\n\u003cp\u003eassociated with doses over 10 g.\u003cspan\u003e7\u003c\/span\u003e The loading phase is followed by a daily lower maintenance dose of 3 to 5\u003c\/p\u003e\n\u003cp\u003eg.\u003cspan\u003e8\u003c\/span\u003e A 1996 landmark study comparing creatine loading with an everyday maintenance dose found that creatine\u003c\/p\u003e\n\u003cp\u003eaccumulation in muscle was similar when consumed as a dose of 3 g for 28 days or as 20 g for 6 days.\u003cspan\u003e9\u003c\/span\u003e Dosage\u003c\/p\u003e\n\u003cp\u003erecommendations and whether to load for a short period or take a smaller dose for a longer period may depend\u003c\/p\u003e\n\u003cp\u003eon the goal of the individual,\u003cspan\u003e8\u003c\/span\u003e but it has been established that both loading- and maintenance-dose strategies\u003c\/p\u003e\n\u003cp\u003ecan increase creatine stores in skeletal muscle.*\u003cspan\u003e3\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMuscle Performance\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eA substantial body of research has established a role for supplemental creatine in fueling muscles and exercise\u003c\/p\u003e\n\u003cp\u003eperformance in individuals from across diverse populations and with varying levels of physical activity. Creatine\u003c\/p\u003e\n\u003cp\u003esupports muscle performance by boosting ATP production to help muscles contract when anaerobic activity is\u003c\/p\u003e\n\u003cp\u003einitiated and helping to maintain a continuous energy supply to the muscle cells when exercising.*\u003cspan\u003e2,5\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eAthletes\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003eIn a randomized trial in football players (N = 16) designed to assess the long-term effects of creatine on strength\u003c\/p\u003e\n\u003cp\u003eand power indices during resistance training, subjects were given 5 g of creatine once daily for 10 weeks. The\u003c\/p\u003e\n\u003cp\u003eresults showed significant increases in muscle performance, strength, and lean body mass, establishing the\u003c\/p\u003e\n\u003cp\u003ebenefit of low-dose creatine on muscle performance without a loading phase.*\u003cspan\u003e10\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eContinued on next page\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCreatine PURE\u003c\/p\u003e\n\u003cp\u003eCreatine PURE\u003c\/p\u003e\n\u003cp\u003eAll DOCTOR RHONDA Formulas Meet or Exceed cGMP Quality Standards\u003cspan\u003e\u003ci\u003eYoung Adult Men\u003c\/i\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIn a study of healthy men (N = 58) aged 21 ± 2 years who regularly engaged in varying levels of recreational\u003c\/p\u003e\n\u003cp\u003eexercise, it was found that 5 g of creatine once daily for 30 days, in combination with resistance training, led to a\u003c\/p\u003e\n\u003cp\u003esignificant improvement in body mass, mean power, and leg and bench press strength. These results indicate a\u003c\/p\u003e\n\u003cp\u003ebenefit to muscle performance post-creatine supplementation.*\u003cspan\u003e11\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOlder Women\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003eIn a study assessing the effect of creatine combined with resistance training on strength, performance, and body\u003c\/p\u003e\n\u003cp\u003ecomposition in older women (N = 18), subjects were given 5 g of creatine or placebo once daily for 12 weeks.\u003c\/p\u003e\n\u003cp\u003eResults indicated an improvement in muscle performance and lean muscle mass in older women when creatine\u003c\/p\u003e\n\u003cp\u003ewas combined with resistance training.*\u003cspan\u003e12\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOlder Adults\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003eIn a pilot study in healthy male and female adults (N = 26) over age 60, researchers sought to establish the\u003c\/p\u003e\n\u003cp\u003eeffect of strength training when combined with 5 g\/d of creatine for 16 weeks. Using a hand dynamometer to\u003c\/p\u003e\n\u003cp\u003emeasure strength and a questionnaire designed to assess cognitive performance, it was determined that creatine\u003c\/p\u003e\n\u003cp\u003esupplementation results in improvements in both strength and cognitive function.*\u003cspan\u003e13\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCognitive Function\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe functional role of creatine in cellular energy metabolism, combined with its well-established role in muscle\u003c\/p\u003e\n\u003cp\u003eperformance, has led to additional studies evaluating its potential to boost brain performance.*\u003cspan\u003e14,15\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIn a placebo-controlled trial in young vegetarian adults (N = 45), the effect of creatine on intelligence test scores\u003c\/p\u003e\n\u003cp\u003eand working memory performance was assessed. Subjects were given 5 g\/d of creatine for 6 weeks, which\u003c\/p\u003e\n\u003cp\u003esignificantly affected working memory and intelligence tasks. These results suggested a beneficial effect of\u003c\/p\u003e\n\u003cp\u003ecreatine on mental performance.\u003cspan\u003e14\u003c\/span\u003e In a larger study (N = 148) that replicated the same design and treatment but\u003c\/p\u003e\n\u003cp\u003eincluded a larger range of cognitive function assessments, creatine was found to have a small beneficial effect.\u003c\/p\u003e\n\u003cp\u003eAlthough the authors did not come to strong conclusions, they suggested that the role of creatine on cognitive\u003c\/p\u003e\n\u003cp\u003eperformance should be further investigated, given that a small effect could have larger benefits when scaled over\u003c\/p\u003e\n\u003cp\u003etime to a larger population group.*\u003cspan\u003e15\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIn a double-blind, placebo-controlled trial, the effect of short-term creatine supplementation on cognitive\u003c\/p\u003e\n\u003cp\u003eperformance was assessed in healthy young adults (N = 24). It was found that cognitive decline associated with\u003c\/p\u003e\n\u003cp\u003emental fatigue, as measured by a standardized calculation test, was reduced with creatine supplementation of 8\u003c\/p\u003e\n\u003cp\u003eg\/d for 5 days.*\u003cspan\u003e16\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eStudies have suggested that creatine supplementation may promote cognitive function in the aging population.\u003cspan\u003e17,18\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eA meta-analysis of data from 8 randomized trials in older adults aged 66 to 76 found that creatine supplementation\u003c\/p\u003e\n\u003cp\u003eenhanced measures of memory performance regardless of dose, duration of intervention, sex, or geographical\u003c\/p\u003e\n\u003cp\u003elocation.\u003cspan\u003e17\u003c\/span\u003e Another meta-analysis of 16 randomized trials with subjects ranging in age from 20 to 76 indicated\u003c\/p\u003e\n\u003cp\u003ethat creatine may confer beneficial cognitive effects, particularly in the domains of memory, attention time, and\u003c\/p\u003e\n\u003cp\u003eprocessing speed. However, the authors suggested further research to elucidate dose, intervention duration, and\u003c\/p\u003e\n\u003cp\u003eprecise mechanisms of action.*\u003cspan\u003e18\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eOverall, a link between creatine and cognitive function has been noted in the research; however, additional and\u003c\/p\u003e\n\u003cp\u003emore robust trials are needed to further validate the impact of creatine supplementation on enhanced cognitive\u003c\/p\u003e\n\u003cp\u003efunction.*\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eLean Muscle Mass\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIn addition to muscle performance and cognitive function, studies have also explored a role for supplemental\u003c\/p\u003e\n\u003cp\u003ecreatine in promoting lean muscle mass. In the aging population, creatine has been demonstrated to improve the\u003c\/p\u003e\n\u003cp\u003equality of life by increasing muscle strength and resistance to fatigue. It has also been demonstrated to increase\u003c\/p\u003e\n\u003cp\u003elean body mass in both younger and older adults when combined with resistance training.*\u003cspan\u003e19,20\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIn a 12-week, parallel-group, double-blind trial, subjects (N = 32) aged 60 to 80 were given 5 g\/d of creatine or\u003c\/p\u003e\n\u003cp\u003eplacebo after resistance training sessions. Participants were assessed for lean mass and strength using dual-\u003c\/p\u003e\n\u003cp\u003eenergy X-ray absorptiometry (DXA) and 10-repetition maximal tests. Results indicated a significant gain in lean\u003c\/p\u003e\n\u003cp\u003emuscle mass when creatine supplementation was combined with resistance training.*\u003cspan\u003e21\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIn a meta-analysis of 19 studies in adults over age 50 (N = 609), the combined effect of creatine supplementation\u003c\/p\u003e\n\u003cp\u003eand resistance training was compared with resistance training alone. Results suggested that creatine combined\u003c\/p\u003e\n\u003cp\u003ewith resistance training has the potential to contribute to a greater reduction in body fat percentage.*\u003cspan\u003e22\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eA meta-analysis of data from randomized clinical trials in generally healthy young, middle-aged, and older adults\u003c\/p\u003e\n\u003cp\u003esuggested that 5 to 20 g of creatine daily for up to 48 weeks, combined with resistance exercise, increased lean\u003c\/p\u003e\n\u003cp\u003ebody mass regardless of age. Neither statistical nor clinical significance in lean body mass was documented for\u003c\/p\u003e\n\u003cp\u003ecreatine supplementation without exercise.*\u003cspan\u003e19\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eThis formulation is designed to provide a daily maintenance dose of creatine to fuel and replenish cellular energy\u003c\/p\u003e\n\u003cp\u003eproduction in tissues where creatine is stored. Widely used by both athletes and individuals concerned about\u003c\/p\u003e\n\u003cp\u003eage-related lean muscle loss, creatine supports muscle performance and may also support cognitive function.*\u003cspan\u003eServing Size: 1 Scoop (about 5 g)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eServings Per Container: About 90\u003c\/p\u003e\n\u003cp\u003e** Daily Value not established.\u003c\/p\u003e\n\u003cp\u003eSupplement Facts\u003c\/p\u003e\n\u003cp\u003eAmount Per Serving %Daily Value\u003c\/p\u003e\n\u003cp\u003e5 g\u003c\/p\u003e\n\u003cp\u003eCreatine monohydrate **\u003c\/p\u003e\n\u003cp\u003eOther Ingredients: None.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCreatine PURE 90 Servings\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eREV. 12\/08\/25\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e*These statements have not been evaluated by the Food and Drug Administration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDRS-369\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eDirections\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eDissolve 1 level scoop in 8 oz of water or other beverage and\u003c\/p\u003e\n\u003cp\u003econsume once daily, or use as directed by your healthcare\u003c\/p\u003e\n\u003cp\u003eprofessional. Can be used 30 minutes before exercise or\u003c\/p\u003e\n\u003cp\u003eimmediately following exercise.\u003c\/p\u003e\n\u003cp\u003eConsult your healthcare professional prior to use. Individuals\u003c\/p\u003e\n\u003cp\u003etaking medication should discuss potential interactions with their\u003c\/p\u003e\n\u003cp\u003ehealthcare professional. Do not use if tamper seal is damaged.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eReferences\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFormulated To Exclude\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eWheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically\u003c\/p\u003e\n\u003cp\u003emodified organisms (GMOs), artificial colors, and artificial sweeteners.\u003c\/p\u003e\n\u003cp\u003e1. Dietary Supplements for Exercise and Athletic Performance Fact Sheet. Updated April 1, 2024. Accessed February 19, 2025. https:\/\/ods.od.nih.gov\/factsheets\/ExerciseAndAthleticPerformance-HealthProfessional\/\u003c\/p\u003e\n\u003cp\u003e2. Kreider RB, Stout JR. \u003ci\u003eNutrients\u003c\/i\u003e. 2021;13(2):447. doi:10.3390\/nu13020447\u003c\/p\u003e\n\u003cp\u003e3. Antonio J, Brown AF, Candow DG, et al. \u003ci\u003eJ Int Soc Sports Nutr\u003c\/i\u003e. 2025;22(1):2441760. doi:10.1080\/15502783.2024.2441760\u003c\/p\u003e\n\u003cp\u003e4. Smith RN, Agharkar AS, Gonzales EB. \u003ci\u003eF1000Res.\u003c\/i\u003e 2014;3:222. doi:10.12688\/f1000research.5218.1\u003c\/p\u003e\n\u003cp\u003e5. Wax B, Kerksick CM, Jagim AR, et al.\u003ci\u003e Nutrients\u003c\/i\u003e. 2021;13(6):1915. doi:10.3390\/nu13061915\u003c\/p\u003e\n\u003cp\u003e6. Bonilla DA, Kreider RB, Stout JR, et al. \u003ci\u003eNutrients.\u003c\/i\u003e 2021;13(4):1238. doi:10.3390\/nu13041238\u003c\/p\u003e\n\u003cp\u003e7. Ostojic SM, Ahmetovic Z. \u003ci\u003eRes Sports Med\u003c\/i\u003e. 2008;16(1):15-22. doi:10.1080\/15438620701693280\u003c\/p\u003e\n\u003cp\u003e8. Antonio J, Candow DG, Forbes SC, et al. \u003ci\u003eJ Int Soc Sports Nutr.\u003c\/i\u003e 2021;18(1):13. doi:10.1186\/s12970-021-00412-w\u003c\/p\u003e\n\u003cp\u003e9. Hultman E, Söderlund K, Timmons JA, et al. \u003ci\u003eJ Appl Physiol\u003c\/i\u003e (1985). 1996;81(1):232-237. doi:10.1152\/jappl.1996.81.1.232\u003c\/p\u003e\n\u003cp\u003e10. Pearson DR, Russel DG, Harris T. \u003ci\u003eJ Strength Cond Res\u003c\/i\u003e. 1999;13(3):187-192.\u003c\/p\u003e\n\u003cp\u003e11. Herda TJ, Beck TW, Ryan ED, et al. \u003ci\u003eJ Strength Cond Res.\u003c\/i\u003e 2009;23(3):818-826. doi:10.1519\/JSC.0b013e3181a2ed11\u003c\/p\u003e\n\u003cp\u003e12. Aguiar AF, Januário RS, Junior RP, et al. \u003ci\u003eEur J Appl Physiol\u003c\/i\u003e. 2013;113(4):987-996. doi:10.1007\/s00421-012-2514-6\u003c\/p\u003e\n\u003cp\u003e13. Smolarek AC, McAnulty SR, Ferreira LH, et al. \u003ci\u003eJEPonline.\u003c\/i\u003e 2020;23(4):88-94.\u003c\/p\u003e\n\u003cp\u003e14. Rae C, Digney AL, McEwan SR, et al. \u003ci\u003eProc Biol Sci\u003c\/i\u003e. 2003;270(1529):2147-50. doi:10.1098\/rspb.2003.2492\u003c\/p\u003e\n\u003cp\u003e15. Sandkühler JF, Kersting X, Faust A, et al. \u003ci\u003eBMC Med\u003c\/i\u003e. 2023;21(1):440. doi:10.1186\/s12916-023-03146-5\u003c\/p\u003e\n\u003cp\u003e16. Watanabe A, Kato N, Kato T. \u003ci\u003eNeurosci Re\u003c\/i\u003es. 2002;42(4):279-285. doi:10.1016\/s0168-0102(02)00007-x\u003c\/p\u003e\n\u003cp\u003e17. Prokopidis K, Giannos P, Triantafyllidis KK, et al. \u003ci\u003eNutr Rev\u003c\/i\u003e. 2023;81(4):416-427. doi:10.1093\/nutrit\/nuac064\u003c\/p\u003e\n\u003cp\u003e18. Xu C, Bi S, Zhang W, et al. \u003ci\u003eFront Nutr.\u003c\/i\u003e 2024;11:1424972. doi:10.3389\/fnut.2024.1424972\u003c\/p\u003e\n\u003cp\u003e19. Delpino FM, Figueiredo LM, Forbes SC, et al. \u003ci\u003eNutrition\u003c\/i\u003e. 2022;103-104:111791. doi:10.1016\/j.nut.2022.111791\u003c\/p\u003e\n\u003cp\u003e20.Pashayee-Khamene F, Heidari Z, Asbaghi O, et al. \u003ci\u003eJ Int Soc Sports Nutr.\u003c\/i\u003e 2024;21(1):2380058. doi:10.1080\/15502783.2024.2380058\u003c\/p\u003e\n\u003cp\u003e21. Pinto CL, Botelho PB, Carneiro JA, et al. \u003ci\u003eJ Cachexia Sarcopenia Muscle.\u003c\/i\u003e 2016;7(4):413-421. doi:10.1002\/jcsm.12094\u003c\/p\u003e\n\u003cp\u003e22. Forbes SC, Candow DG, Krentz JR, et al. \u003ci\u003eJ Funct Morphol Kinesiol.\u003c\/i\u003e 2019;4(3):62. doi:10.3390\/jfmk4030062\u003c\/p\u003e","brand":"BioPure by Doctor Rhonda","offers":[{"title":"Default Title","offer_id":52825547538749,"sku":null,"price":0.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0822\/9470\/2397\/files\/CreatinePURE_Creatine90sv_10255995.png?v=1786548944","url":"https:\/\/doctorrhonda.myshopify.com\/products\/creatine-pure","provider":"BioPure by Doctor Rhonda","version":"1.0","type":"link"}