Super SPM

Clinical Application

• Supplies EPA and DHA, Precursors to Pro-Resolving Lipid Mediators
• Promotes Specialized Pro-Resolving Lipid Mediator Activity
• Provides Building Blocks That Support the Natural Resolution of the Immune Response


Super SPM features highly concentrated fish oil with a standardized quantity of the pro-resolvingmediators (PRMs) 18-HEPE, 17-HDHA, and 14-HDHA. Metabolites of PRMs, known as specialized PRMs, provide building blocks to support the natural resolution of the immune response.

Discussion:
Pro-resolving mediators (PRMs) are metabolites of omega-3 and omega-6 fatty acids. The most abundant PRMs are 14-HDHA, 17-HDHA, and 18-HEPE. These PRMs are further metabolized to naturally occurring signaling molecules referred to as specialized PRMs (SPMs). The function of Super SPMs is to downregulate the inflammatory process after the initial immune response, allowing a return to homeostasis. Also known as “resolving agonists,” Super SPMs target specific immune cells to switch off, or resolve, the inflammatory response that naturally occurs with acute injury or illness. Without a resolution, inflammation may linger after the acute phase has passed, leading to an increased risk for significant chronic health issues.

Essential fatty acids are released from circulation to provide the substrate for forming SPMs. The positive benefits of omega-3s for many clinical indications may be attributed to the action of SPMs. The SPM genus is composed of the following 4 structurally distinct, prominent families of signaling molecules: lipoxins derived from arachidonic acid; resolvins derived from eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA); and finally protectins and maresins derived from DPA and DHA. Each SPM has a defined structure that is pivotal to its bioaction. The endogenous biochemical SPM pathways result in counterregulation of the production of pro-inflammatory mediators (cytokines, chemokines, and inflammatory eicosanoids) to support a healthy inflammatory response. As a specific example, the pathways for resolvins are constituted by the fatty acid lipoxygenases and cyclooxygenase-2 via transcellular interactions generated by innate immune effector cells that migrate to inflamed tissue sites from the vasculature. Without control of this response, the activated pro-inflammatory metabolites overwhelm the tissues with persistent inflammatory cell infiltrates and edema, resulting in tissue damage. Super SPM contains an enhanced marine lipid concentrate of omega-3 fatty acid ethyl esters with a standardized level of PRMs. The concentrate is a result of a proprietary fractionation method used to enrich 18-HEPE, 17-HDHA, and 14-HDHA. Metabolites of PRMs are emerging as a promising modality for providing building blocks to support the natural resolution of the immune response.