Ultra Workout Fuel

Discussion

• Enhances Exercise Performance*

• Helps Reduce Muscle Fatigue and Supports Muscle Power, Strength, and

Growth with Peak ATP*

• Supports Recovery*

• Supports ATP Biosynthesis and Muscular Excitability*

• Provides an Alternative to Ordinary Caffeine*

• Supports Electrolyte Replacement*

• Provides Antioxidant Support with S-Acetyl-L-Glutathione and Vitamin C*

Clinical Applications

All-Natural, No Sugars

Ultra Workout Fuel relies on natural ingredients, not ephedra or artificial stimulants, to help maximize exercise performance. Furthermore, it

provides only five grams of carbohydrates and zero sugars. By using natural flavors and stevia in place of sugar and other carbohydrates, the

typical “sugar high” that is associated with many energy drinks can be avoided. Equally important, Ultra Workout Fuel contains no artificial colors.*

Peak ATP®

Oral supplementation of ATP (adenosine triphosphate) combined with resistance training has demonstrated ergogenic benefits.[1] Peak ATP

is a patented form of ATP disodium that has been shown in human studies to enhance muscular growth, power, and strength while improving

recovery. Proposed mechanisms of action include increased muscular excitability, improved blood flow, and increased anabolic signaling.[1-4] As a

result of these effects, Peak ATP helps athletes push themselves to greater levels of performance.*

Peak ATP supplementation (400 mg/d) has been shown to increase post-exercise ATP levels and athletic performance following repeated sprint

bouts. Peak ATP also significantly increased vasodilation and blood flow after acute arm exercise bouts.[5,6] In a double-blind, placebo-controlled,

crossover study, 400 mg of Peak ATP for 15 days “tended to reduce muscle fatigue while improving muscle low-peak torque through sets

of exhaustive exercise.”[1] A double-blind placebo-controlled study showed that resistance-trained participants taking Peak ATP for 12 weeks

experienced several benefits over placebo, such as increased strength (147%), increased power (30%), increased lean body mass (100%),

and increased muscle thickness (96%). Additionally, body fat decreased in the supplemented group.[3] Data also suggests that Peak ATP helped

prevent performance declines seen in overreaching.[3] Adding to these findings, in a randomized, double-blind, placebo-controlled study (n=42),

Purpura et al found that 400 mg of Peak ATP for two weeks prevented exercise-induced declines in ATP and its metabolites and enhanced peak

power and muscle excitability.*[7]

Creatine Monohydrate

Creatine supplementation increases the amount of creatine in muscle tissue, heightens energy production, decreases muscle fatigue, and

reduces lactic acid output. Significant improvements in body mass, fat-free body mass, oxygen uptake, sprint performance, weightlifting volumes,

and overall exercise performance following creatine supplementation have been demonstrated.[8-10] In Ultra Workout Fuel, a compounding effect

of several ingredients is expected. In fact, the combinatory effects of caffeine, creatine, and amino acids have produced improvements in time to

exhaustion (TTE) and peak velocity (PV) in humans.*[11]

Caffeine Pterostilbene Co-Crystal

Caffeine pterostilbene co-crystal is an innovative ingredient that combines caffeine with pterostilbene—a highly bioavailable analog of resveratrol—

to form a unique co-crystal structure. It appears that this unique structure affects the way the body utilizes caffeine. As such, it may offer significant

advantages over caffeine alone. In a rat study (n=6), the half-life of caffeine from caffeine pterostilbene co-crystal was eight hours, while that of

ordinary caffeine was just three hours.[12] In a preliminary, four-week, single-blind, crossover human study (n=12) that compared 232 mg of caffeine

pterostilbene co-crystal (providing 99.76 mg of caffeine) to 100 mg of ordinary caffeine, the absorption of caffeine from caffeine pterostilbene co-

crystal was approximately 30% slower and caffeine pterostilbene co-crystal delivered 30% more caffeine to the bloodstream. Furthermore, at six

hours, 51% more caffeine from caffeine pterostilbene co-crystal was detected in serum compared to ordinary caffeine.*[13,14]

These data suggest that the effects of caffeine from caffeine pterostilbene co-crystal may last longer than the effects from ordinary caffeine

and point to a potential for reducing total caffeine intake. Additionally, the extended half-life and slower absorption rate of caffeine from caffeine

pterostilbene co-crystal may produce a more moderated and gradual finish, thereby preventing the “crash” associated with regular caffeinated

energy products. While the results of these studies are promising, larger studies are needed to validate the findings and determine if these findings

translate into a lengthened energy effect. Of interest, chlorogenic acids from coffee have been found to positively affect human fecal microbiota,

including Bifidobacterium species, which could benefit host health.*[15]

Herbs and Amino Acids

Ultra Workout Fuel combines caffeine pterostilbene co-crystal in a proprietary blend with various herbs and amino acids, including green tea

extract, coffee fruit extract, taurine, and L-arginine alpha-ketoglutarate. This proprietary blend is designed to complement the activities of caffeine

Continued on next page

*These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

Ultra Workout Fuel is designed to meet the demanding needs of the body during and after exercise. This great-tasting drink

mix provides a low-carb, zero-sugar combination of bioactive B vitamins, electrolytes, Albion® chelated trace minerals, key

amino acids, herbs, powerful antioxidants, and a unique blend of natural exercise enhancers to fuel muscular excitability and

promote recovery—without the use of artificial sweeteners.*

Ultra Workout Fuel

Ultra Workout Fuel

All DOCTOR RHONDA Formulas Meet or Exceed cGMP Quality StandardsServing Size: 1 Scoop (about 12.9 g)

Servings Per Container: About 30

† Percent Daily Values are based on a 2,000 calorie diet.

** Daily Value not established.

Supplement Facts

Calories

Total Carbohydrate

Vitamin C (as sodium ascorbate, potassium ascorbate, calcium ascorbate, and zinc ascorbate)

Vitamin E (as d-alpha tocopheryl succinate)

Thiamin (as thiamine HCl)

Riboflavin (as riboflavin 5'-phosphate sodium)

Niacin

Vitamin B6 (as pyridoxal 5’-phosphate)

Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt)S1

Vitamin B12 (as methylcobalamin)

Pantothenic Acid (as d-calcium pantothenate)

Magnesium (as di-magnesium malate)S2

Zinc (as zinc bisglycinate chelate)S2

Manganese (as manganese bisglycinate chelate)S2

Chromium (as chromium nicotinate glycinate chelate)S2

Sodium (as sodium bicarbonate and sodium ascorbate)

Potassium (potassium bicarbonate and potassium ascorbate)

Creatine (as creatine monohydrate)

Proprietary Blend

Caffeine pterostilbene cocrystal, whole coffee fruit (Coffea arabica)(whole fruit)

(40% chlorogenic acid), taurine, L-arginine alpha-ketoglutarate, organic green tea aqueous extract

(Camellia sinensis)(leaf)(25% polyphenols, 15% catechins, <10% caffeine), s-acetyl-L-glutathione,

and acetyl-L-carnitine (as acetyl-L-carnitine HCl), yielding a total of 95 mg of caffeine.

Adenosine 5' Triphosphate DisodiumS3

Amount Per Serving %Daily Value

45

4 g

500 mg

10 mg

0.45 mg

0.5 mg

10 mg

2.6 mg

68 mcg DFE

2,500 mcg

3 mg

150 mg

3 mg

0.5 mg

100 mcg

135 mg

215 mg

3 g

465 mg

400 mg

1%†

556%

67%

38%

38%

63%

153%

17%

104,167%

60%

36%

27%

22%

286%

6%

5%

**

**

**

Other Ingredients: Maltodextrin, citric acid, malic acid, natural flavors (no MSG), natural grape powder, stevia leaf extract,

and silica.

S1. Quatrefolic® is a registered trademark of Gnosis S.p.A.

Produced under U.S. patent 7,947,662.

S2. Albion® is a registered trademark of Balchem Corporation or its subsidiaries.

S3. PEAK ATP® is a registered trademark of

TSI, Inc. and is used under license.

DRS-299

REV. 02/12/25

*These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

Dissolve the contents of 1 scoop in 6-12 oz of water according to

preferred taste. On non-workout days, consume the effervescent drink

in the morning on on empty stomach. On workout days, consume the

effervescent drink once doily 30 minutes prior to workout, or use as

directed by your healthcare professional.

Consult your healthcare professional prior to use. Individuals toking

medication, especially blood thinners, should discuss potential interactions

with their healthcare professional. Caffeine should not be combined with

synephrine or ephedrine. Use cautiously if you hove a history of abnormal

heart rhythm. Do not use if tamper seal is damaged.

Directions

Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, artificial colors, and artificial

sweeteners.

References

Formulated To Exclude

pterostilbene co-crystal. Furthermore, some of these individual ingredients

taken in high doses have roles in mitochondrial biogenesis and are known

to have a positive influence on exercise performance.*[16-18]

Electrolytes and Antioxidants

Electrolytes—including sodium, potassium, and magnesium—are

important for energy production, nerve transmission, muscle contractions,

pH balance, fluid balance, and more. Conditions that promote excessive

sweating and increased metabolic activity can require replacement of

these important minerals and increase the need for antioxidants. Ultra

Workout Fuel provides 130 mg of sodium, 280 mg of potassium, and 150

mg of magnesium in each serving. To support protection from free radicals,

Ultra Workout Fuel provides 500 mg of vitamin C in the form of four mineral

ascorbates, as well as natural vitamin E, selenium, green tea extract, and

s-acetyl-L-glutathione (SAG). SAG is an orally stable glutathione that has

been shown to cross the membrane of the mitochondria, which increases

the organelle’s activity and helps minimize reactive oxygen species.*

B Vitamins

The B vitamins provided in Ultra Workout Fuel are in their activated forms

to optimize bioavailability and utilization. As essential parts of coenzymes,

these water-soluble nutrients are integral to the complex biochemical

processes that convert food to glucose and ATP—the energy used by

cells. Vitamin B12 also works closely with folate to help make red blood

cells and facilitate the work of iron in the body. Iron helps carry oxygen to

all cells, including muscle cells, for use in the generation of energy.*

1. Rathmacher JA, Fuller JC Jr, Baier SM, et al. Adenosine-5’-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity

exercise sets. J Int Soc Sports Nutr. 2012 Oct 9;9(1):48. [PMID: 23046855]

2. Jäger R, Roberts MD, Lowery RP, et al. Oral adenosine-5’-triphosphate (ATP) administration increases blood flow following exercise in animals and humans. J Int Soc Sports Nutr.

2014 Jun 13;11:28. [PMID: 25006331]

3. Wilson JM, Joy JM, Lowery RP, et al. Effects of oral adenosine-5’-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained

men. Nutr Metab (Lond). 2013 Sep 22;10(1):57. [PMID: 24330670]

4. Kichenin K, Decollogne S, Angignard J, et al. Cardiovascular and pulmonary response to oral administration of ATP in rabbits. J Appl Physiol (1985). 2000 Jun;88(6):1962-8. [PMID:

10846006]

5. Rauch J, Lowery RP, Silva J, et al. The oral bioavailability of ATP following an intense sprinting protocol. In: National Strength and Conditioning Association 2014 Annual Meeting, Las

Vegas, NV. J Strength Cond Res. 2014;28(suppl 2):S53-S54. http://journals.lww.com/nsca-jscr/Fulltext/2014/12001/NSCA_2014_Annual_Meeting.1.aspx. Accessed September 29, 2015.

6. Lowery R, Roberts M, Booth F, et al. Oral ATP administration improves blood flow responses to exercise in both animal and human training models. In: Proceedings of the Tenth

International Society of Sports Nutrition (ISSN) Conference and Expo, Colorado Springs, CO. J Int Soc Sports Nutr. 2013;10(suppl 1):P16. http://www.jissn.com/content/10/S1/P16.

Accessed September 29, 2015.

7. Purpura M, Rathmacher JA, Sharp MH, et al. Oral adenosine-5’-triphosphate (ATP) administration increases postexercise ATP levels, muscle excitability, and athletic performance

following a repeated sprint bout. J Am Coll Nutr. 2017 Jan 12:1-7. [PMID: 28080323]

8. Smith RN, Agharkar AS, Gonzales EB. A review of creatine supplementation in age-related diseases: more than a supplement for athletes. F1000Res. 2014 Sep 15;3:222. [PMID:

25664170]

9. Aguiar AF, Januário RS, Junior RP, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. 2013

Apr;113(4):987-96. [PMID: 23053133]

10. Bemben MG, Lamont HS. Creatine supplementation and exercise performance: recent findings. Sports Med. 2005;35(2):107-25. [PMID: 15707376]

11. Fukuda DH, Smith AE, Kendall KL, et al. The possible combinatory effects of acute consumption of caffeine, creatine, and amino acids on the improvement of anaerobic running

performance in humans. Nutr Res. 2010 Sep;30(9):607-14. [PMID: 20934602]

12. Single-dose comparative pharmacokinetic study of pterostilbene, caffeine and combination of pterostilbene caffeine co-crystal in SD rats by oral route. Study report. Study No:

VLL/0912/NG/D033; Version No.: 1.0. Genome Valley, Hyderabad, India: Vimta Labs Limited; November 2012:1-25. [on file]

13. A crossover, clinical evaluation to determine the relative bioavailability, pharmacokinetics and safety of PURENERGY™ and pTeroPure® in healthy adult males. PK study summary.

Miami, FL/Irvine, CA: Miami Research Associates/ChromaDex Inc.; 2013:1-34. [on file]

14. Purenergy™: A novel next-generation caffeine alternative. Irvine, CA: ChromaDex Inc.; September 10, 2014:1-5. [on file]

15. Mills CE, Tzounis X, Oruna-Concha MJ, et al. In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth. Br J Nutr.

2015 Apr 28;113(8):1220-27. [PMID: 25809126]

16. Campbell B, Roberts M, Kerksick C, et al. Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men. Nutrition. 2006

Sep;22(9):872-81. [PMID: 16928472]

17. Flôres MF, Martins A, Schimidt HL, et al. Effects of green tea and physical exercise on memory impairments associated with aging. Neurochem Int. 2014 Sep 6. [PMID: 25195719]

18. Pandareesh MD, Anand T. Ergogenic effect of dietary L-carnitine and fat supplementation against exercise induced physical fatigue in Wistar rats. J Physiol Biochem. 2013

Dec;69(4):799-809. [PMID: 23661316]